Assuntos
Toxinas Botulínicas Tipo A , Hidrocistoma , Hiperidrose , Neoplasias das Glândulas Sudoríparas , Humanos , Hidrocistoma/complicações , Hidrocistoma/tratamento farmacológico , Toxinas Botulínicas Tipo A/uso terapêutico , Hiperidrose/tratamento farmacológico , Neoplasias das Glândulas Sudoríparas/tratamento farmacológico , Resultado do TratamentoRESUMO
Apocrine hidrocystoma (AH) is a benign cystic lesion infrequently reported in the eyelids of cats. There are several reports of application of trichloroacetic acid (TCA) for treatment of eyelid apocrine hidrocystomas with high success rates in humans. This is the first report of intralesional injection of TCA for the treatment of eyelid AH in a feline. A 12-year-old Persian female spayed cat has been presented for evaluation of cystic masses on the eyelids. The cat had signs of ocular discomfort and two large cysts on the lower eyelid of the right eye. Ophthalmic examination was suggestive of eyelid AH. The cat underwent general anesthesia, and TCA 20 % was injected intracystically. The diagnosis of AH was confirmed by cytology. Two years later, there was no recurrence of the cyst. This case highlights the successful treatment of a large AH in the eyelids of a cat with TCA. Findings suggest that chemical ablation with TCA may be a useful treatment for AH in cats.
Assuntos
Doenças do Gato , Hidrocistoma , Neoplasias das Glândulas Sudoríparas , Animais , Doenças do Gato/tratamento farmacológico , Gatos , Pálpebras , Feminino , Hidrocistoma/tratamento farmacológico , Hidrocistoma/veterinária , Injeções/veterinária , Neoplasias das Glândulas Sudoríparas/tratamento farmacológico , Neoplasias das Glândulas Sudoríparas/veterinária , Ácido Tricloroacético/uso terapêuticoRESUMO
Eccrine hidrocystomas (EH) are benign cystic tumors of the eccrine glands with no established treatment yet. Eccrine glands are activated by acetylcholine released from innervating sympathetic nerve fibers. Use of oral anti-cholinergic agents is rare due to the possibility of systemic side effects while topical atropine and scopolamine have been found to be ineffective. In our patient, we tried using topical glycopyrrolate over the entire affected region followed by microneedling. Our aim was to create micro-channels through the epidermis and dermis, delivering the drug to EH lesions in the deeper dermis. We only performed microneedling over the left half of the chest to compare the difference made by microneedling. The effective percutaneous delivery of topical glycol was evident by our patient's transient systemic side effects and reduction of the EH lesions. Specifically, the lesions were reduced more significantly over the left where microneedles were applied. Our treatment was effective for our patient and he was satisfied with the improvement in cosmesis. The method described may serve as a therapeutic option for patients with EH.
Assuntos
Hidrocistoma , Neoplasias das Glândulas Sudoríparas , Glândulas Écrinas , Epiderme , Glicopirrolato/uso terapêutico , Hidrocistoma/tratamento farmacológico , Humanos , Masculino , Neoplasias das Glândulas Sudoríparas/tratamento farmacológicoRESUMO
Botulinum toxin type A (BoNTA) is a powerful neurotoxin that inhibits acetylcholine release from presynaptic vesicles. The potency and safety profile of BoNTA grant the toxin vast therapeutic potential. It has been used off-label for a variety of dermatologic conditions. This review aims to analyze published literature regarding the benefits and risks of the off-label use of BoNTA beyond facial lines, including eccrine hidrocystomas, enlarged pores, keloids and hypertrophic scars, hidradenitis suppurativa, hyperhidrosis, masseter muscle hypertrophy, and salivary gland hypertrophy, among others. A MEDLINE search from January 2000 to December 2019 was conducted on the off-label uses of botulinum toxin in dermatology.
Assuntos
Inibidores da Liberação da Acetilcolina/administração & dosagem , Toxinas Botulínicas Tipo A/administração & dosagem , Dermatologia/métodos , Uso Off-Label , Inibidores da Liberação da Acetilcolina/efeitos adversos , Toxinas Botulínicas Tipo A/efeitos adversos , Cicatriz Hipertrófica/tratamento farmacológico , Dermatologia/normas , Hidradenite Supurativa/tratamento farmacológico , Hidrocistoma/tratamento farmacológico , Humanos , Hiperidrose/tratamento farmacológico , Hipertrofia/tratamento farmacológico , Injeções Intralesionais/métodos , Injeções Intralesionais/normas , Injeções Subcutâneas/métodos , Injeções Subcutâneas/normas , Queloide/tratamento farmacológico , Músculo Masseter/anormalidades , Ensaios Clínicos Controlados Aleatórios como Assunto , Glândulas Salivares/patologia , Neoplasias das Glândulas Sudoríparas/tratamento farmacológico , Resultado do TratamentoAssuntos
Face/patologia , Hidrocistoma/diagnóstico , Neoplasias das Glândulas Sudoríparas/patologia , Biópsia/métodos , Toxinas Botulínicas Tipo A/administração & dosagem , Toxinas Botulínicas Tipo A/uso terapêutico , Antagonistas Colinérgicos/administração & dosagem , Antagonistas Colinérgicos/uso terapêutico , Diagnóstico Diferencial , Feminino , Hidrocistoma/tratamento farmacológico , Humanos , Pessoa de Meia-Idade , Fármacos Neuromusculares/administração & dosagem , Fármacos Neuromusculares/uso terapêuticoAssuntos
Glândulas Apócrinas , Meato Acústico Externo , Hidrocistoma/patologia , Glândulas Apócrinas/patologia , Meato Acústico Externo/patologia , Hidrocistoma/diagnóstico , Hidrocistoma/tratamento farmacológico , Hidrocistoma/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Nistatina/administração & dosagem , Pomadas , Recidiva , Resultado do Tratamento , Triancinolona/administração & dosagemRESUMO
Eccrine hidrocystomes (EH) are benign cystic tumors of dermal eccrine ducts. There is still no gold standard treatment option for EH because of the large number of lesions, the risk of cicatrization and the different treatment options offered. We offer combined oral isotretinoin and following erbium-yttrium aluminum garnet laser treatment as an alternative treatment option in difficult patients with EH.
Assuntos
Fármacos Dermatológicos/uso terapêutico , Hidrocistoma/terapia , Isotretinoína/uso terapêutico , Terapia Combinada , Hidrocistoma/tratamento farmacológico , Hidrocistoma/radioterapia , Humanos , Lasers de Estado Sólido , Terapia com Luz de Baixa Intensidade , Masculino , Pessoa de Meia-IdadeAssuntos
Compostos de Alumínio/administração & dosagem , Antineoplásicos/administração & dosagem , Cloretos/administração & dosagem , Hidrocistoma/tratamento farmacológico , Neoplasias das Glândulas Sudoríparas/tratamento farmacológico , Administração Tópica , Adulto , Feminino , Humanos , Resultado do TratamentoRESUMO
BACKGROUND: Multiple eccrine hidrocystomas (MEH) are benign cystic lesions of the sweat gland ducts. They are characterized by translucent, skin-colored or bluish dome-shaped papules on the face, causing cosmetic concern. Recently, botulinum toxin-A, because of its antiperspirant properties, has been used to treat facial MEH. However, there are only some case reports in the literature. OBJECTIVE: Here, we conducted a prospective study to assess the efficacy and safety of intralesional injection of botulinum toxin-A (Dysport) for the treatment of MEH. MATERIAL AND METHODS: Twenty patients (3 men and 17 women), aged from 31 to 75 years old, participated in this study. A 300 unit vial of botulinum toxin-A (Dysport, Ipsenn Biopharm, United Kingdom) was diluted with 4 ml of saline solution without preservative to achieve a concentration of 7.5U/.1 ml. Up to 1.5 unit of botulinum toxin was injected intradermally at the base of each lesion to raise a visible wheal. The patients were evaluated 7 days later, and any clinical changes or adverse effects were recorded. RESULTS: In all patients, more than 75% of eccrine hidrocystoma lesions resolved without any scaring. The result sustained for 2-5 months. In two patients mild smile asymmetry and in one patient lagophthalmos were noted approximately 5-7 days after injection that gradually resolved in 3 weeks. CONCLUSION: Intralesional botulinum toxin-A for treatment of multiple hidrocystomas is a simple and well-tolerated procedure. It is accompanied by excellent results, a good postoperative course, and no risk of scarring. It can be considered in patients who did not respond to other treatment or even as the first line therapy.
Assuntos
Toxinas Botulínicas Tipo A/administração & dosagem , Neoplasias Faciais/tratamento farmacológico , Hidrocistoma/tratamento farmacológico , Neoplasias Primárias Múltiplas/tratamento farmacológico , Fármacos Neuromusculares/administração & dosagem , Neoplasias das Glândulas Sudoríparas/tratamento farmacológico , Adulto , Idoso , Toxinas Botulínicas Tipo A/efeitos adversos , Feminino , Humanos , Injeções Intralesionais , Masculino , Pessoa de Meia-Idade , Fármacos Neuromusculares/efeitos adversos , Estudos Prospectivos , Resultado do TratamentoRESUMO
Multiple eccrine hidrocystoma (EH) has been treated with topical atropine with variable results. However, in rare cases, anticholinergic side effects have been seen after the use of the topical form of this drug. We presented a 50-year-old woman who developed recent onset of visual disturbance and photophobia from 2 weeks prior. The diagnosis of topical atropine-induced bilateral mydriasis was made. We reported a recognized but often overlooked case of bilateral mydriasis caused by application of topical 1% atropine for treatment of multiple EH.
Assuntos
Atropina/efeitos adversos , Hidrocistoma/tratamento farmacológico , Antagonistas Muscarínicos/efeitos adversos , Midríase/induzido quimicamente , Neoplasias Primárias Múltiplas/tratamento farmacológico , Neoplasias das Glândulas Sudoríparas/tratamento farmacológico , Atropina/administração & dosagem , Feminino , Humanos , Pessoa de Meia-Idade , Antagonistas Muscarínicos/administração & dosagem , Fotofobia/induzido quimicamenteAssuntos
Neoplasias Faciais/tratamento farmacológico , Hidrocistoma/tratamento farmacológico , Ácidos Mandélicos/uso terapêutico , Neoplasias das Glândulas Sudoríparas/tratamento farmacológico , Administração Oral , Relação Dose-Resposta a Droga , Esquema de Medicação , Estética , Neoplasias Faciais/patologia , Feminino , Seguimentos , Hidrocistoma/patologia , Humanos , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Neoplasias das Glândulas Sudoríparas/patologia , Resultado do TratamentoRESUMO
Apocrine hidrocystomas, while rare, present predominantly as solitary papules occurring in the periocular region of the face. Various treatment modalities for these lesions exist depending on their size and location, but the management of multiple hidrocystomas can be more challenging. Recent reports illustrate that multiple eccrine hidrocystomas have been successfully treated with botulinum toxin A. Herein we describe the effective use of botulinum toxin A in a 29-year-old man with multiple facial apocrine hidrocystomas, which, to our knowledge, has not yet been reported in the English-language literature.
Assuntos
Antineoplásicos/uso terapêutico , Toxinas Botulínicas Tipo A/uso terapêutico , Hidrocistoma/tratamento farmacológico , Neoplasias das Glândulas Sudoríparas/tratamento farmacológico , Adulto , Humanos , Masculino , Resultado do TratamentoAssuntos
Antineoplásicos/administração & dosagem , Glândulas Écrinas/efeitos dos fármacos , Hidrocistoma/tratamento farmacológico , Ácidos Mandélicos/administração & dosagem , Antagonistas Muscarínicos/administração & dosagem , Neoplasias das Glândulas Sudoríparas/tratamento farmacológico , Administração Oral , Adulto , Glândulas Écrinas/patologia , Feminino , Hidrocistoma/diagnóstico , Humanos , Neoplasias das Glândulas Sudoríparas/diagnóstico , Resultado do TratamentoAssuntos
Hidrocistoma/diagnóstico , Neoplasias Nasais/diagnóstico , Neoplasias das Glândulas Sudoríparas/diagnóstico , Cloreto de Alumínio , Compostos de Alumínio/uso terapêutico , Pré-Escolar , Cloretos/uso terapêutico , Hidrocistoma/tratamento farmacológico , Hidrocistoma/patologia , Humanos , Masculino , Neoplasias Nasais/tratamento farmacológico , Neoplasias Nasais/patologia , Neoplasias das Glândulas Sudoríparas/tratamento farmacológico , Neoplasias das Glândulas Sudoríparas/patologia , Resultado do TratamentoRESUMO
Eccrine hidrocystoma is a benign tumor derived from eccrine sudoriparous glands. Most eccrine hidrocystomas are solitary and asymptomatic lesions. Multiple hidrocystomas are unusual and have been associated with Graves' disease, Parkinson's disease, and idiopathic craniofacial hyperhidrosis. This report describes the successful treatment of multiple center facial eccrine hidrocystomas associated with craniofacial hyperhidrosis with 0.5% glycopyrrolate aqueous solution applied locally for 1 week. The present authors obtained a very significant improvement without leaving any trace of clinical examination. Multiple eccrine hidrocystomas are a rare condition and, to date, no effective treatment has been reported. Topical glycopyrrolate is a very good first-line treatment option.
Assuntos
Neoplasias Palpebrais/tratamento farmacológico , Glicopirrolato/uso terapêutico , Hidrocistoma/tratamento farmacológico , Hiperidrose/tratamento farmacológico , Antagonistas Muscarínicos/uso terapêutico , Neoplasias das Glândulas Sudoríparas/tratamento farmacológico , Administração Cutânea , Glândulas Écrinas/patologia , Feminino , Glicopirrolato/administração & dosagem , Hidrocistoma/patologia , Humanos , Hiperidrose/patologia , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
Botulinum toxin could represent nowadays a new treatment modality especially for cutaneous conditions in course of which conventional treatments remain unsuccessful. Besides palmar and plantar hyperhidrosis, botulinum toxin has demonstrated efficacy in different conditions associated with hyperhidrosis, such as dyshidrosis, multiple eccrine hidrocystomas, hidradenitis suppurativa, Frey syndrome, but also in different conditions worsened by hyperhidrosis such as Hailey-Hailey disease, Darier disease, inversed psoriasis, aquagenic palmoplantar keratoderma, pachyonychia congenital. Moreover, different cutaneous conditions associated with sensitive disorders and/or neurological involvements could benefit from botulinum toxin, for example anal fissures, leg ulcers, lichen simplex, notalgia paresthetica, vestibulitis. Endly, a case of cutis laxa was described where the patient was improved by cutaneous injections of botulinum toxin.